Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (N-Term) Peptide
ACCN2
Reactivity: Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN972800
Quick Overview for Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (N-Term) Peptide (ABIN972800)
Target
ASIC1 (ACCN2)
(Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- MELKTEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Accn2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) peptide
ACCN2 Host: Synthetic BP, WB, IHC
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
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Background
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Accn2 is a cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. It also permeable for Ca2+, Li+ and K+. It generates a biphasic current with a fast inactivating and a slow sustained phase and mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Accn2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear.
Alias Symbols: AI843610, ASIC, ASIC1, ASIC1a, B530003N02Rik, BNaC2, Accn2
Protein Size: 526 -
Molecular Weight
- 60 kDa
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Gene ID
- 11419
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NCBI Accession
- NM_009597, NP_033727
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UniProt
- Q6NXK8
Target
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